Federal Grants
Browse current U.S. federal grants and cooperative agreements from government agencies, with practical guidance on NOFOs, eligibility, and registration.
Federal grants are the largest single pool of grant funding in the United States, but they reward preparation more than inspiration. Every opportunity is governed by a notice of funding opportunity (NOFO) that spells out who can apply, what the money can buy, how applications are scored, and exactly how to submit. Reading the NOFO end to end before deciding to apply is the single highest-value habit in this category, because federal eligibility rules are enforced literally: the wrong applicant type or a missing registration ends the application regardless of merit.
The registration pipeline is the part that surprises first-timers. Applying typically requires an active SAM.gov registration, a Unique Entity ID, and an account on Grants.gov or the agency’s own portal, and standing these up can take weeks. If a deadline is close and your organization is not registered, that is usually a reason to target the next cycle rather than rush.
Federal agencies differ sharply in culture. Research agencies score technical merit through peer review; service-oriented agencies score program design, need, and past performance; some programs are formula-based and flow through states rather than accepting direct applications at all. If a federal program routes money through your state, the state agency page, not the federal one, is where you actually apply. Also note whether the instrument is a grant or a cooperative agreement, since the latter means the agency will be actively involved in your project.
Common mistakes: budgeting outside the eligible-cost rules, ignoring the mandatory formatting and page limits, and missing that many programs require matching funds or letters of commitment. Use the listings below to find open federal opportunities, then go straight to the official NOFO and build a compliance checklist before you write.
Current matching opportunities
These listings are limited to open, rolling, or upcoming opportunities that match this guide. Check the official source before applying.
NEH Public Humanities Projects: Exhibitions and Historic Places Grants for Broad Public Engagement
The National Endowment for the Humanities Public Humanities Projects program funds public-facing exhibitions and historic-site interpretation initiatives in U.S. for up to three months of research-to-public delivery in 2026 and 2027.
Postdoctoral Intramural Research Training Awards (IRTA) at the NIH NLM
NIH's NLM Postdoctoral Intramural Research Training Award offers full-time postdoctoral research training in a laboratory with direct mentor support and flexible start timing.
FY 2027 Multistate Conservation Grant Program (F27AS00009)
The FY 2027 Multistate Conservation Grant Program supports multistate wildlife and sport fish restoration and management projects that address AFWA Strategic Priorities across U.S. jurisdictions.
PAR-27-077: NIH Science Education Partnership Award (SEPA) (R25 Clinical Trial Not Allowed)
The NIH reissued PAR-27-077 SEPA to fund pre-K through grade 12 STEM education projects that increase biomedical research understanding and encourage long-term science pathways.
NSF 26-511: SBIR/STTR Pilot Emphasis on Scientific Instrumentation (Phase I, Phase II, Fast-Track)
Current NSF SBIR/STTR solicitation for U.S. small businesses with pilot focus on scientific instrumentation and a 2026-2027 submission cadence.
PAR-25-270: NCCIH Natural Product Early Phase Clinical Trial Award (R33)
NIH NOFO for R33 early-phase natural-product clinical trials focused on target-engagement evidence before larger efficacy studies, with a direct-cost cap of $1,050,000 over up to 3 years and strict clinical-trial-only eligibility.
NIH PAR-25-370: ELSI Small Research Grant (R03 Clinical Trial Optional)
NIH NOFO PAR-25-370 supports small, self-contained ethical, legal, and social implications (ELSI) projects in human genetics and genomics with up to $50,000 direct costs per year and up to two years of support.
RFA-OD-27-008: Maximizing the Scientific Value of ECHO Data (NRSA F32 Postdoctoral Fellowship)
A National Institutes of Health Office of the Director fellowship call for postdoctoral researchers using Environmental Influences on Child Health Outcomes (ECHO) de-identified cohort data through the NICHD DASH repository, with applications due in December 2026 for FY 2027 start cycles.
RFA-HD-27-007: Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research
This NIH RFA requests grant applications that use existing HIV/AIDS archives and biospecimen repositories to generate high-impact research on maternal and pediatric HIV outcomes.
NIGMS Maximizing Investigators' Research Award (MIRA) for Established Investigators (PAR-26-121)
PAR-26-121 is a National Institutes of Health/NIGMS MIRA NOFO for established investigators with a recurring submission cycle in 2026 and 2027.
NIH SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional): PAR-27-098
A late-stage small business commercialization bridge for U.S. NIH SBIR or STTR Phase II projects that need outsourced technical development, clinical studies, or market-readiness work before full commercialization.
PAR-25-449: Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)
A NCCIH phased NIH parent R61/R33 NOFO supporting mind-body mechanistic clinical trials with strong preliminary data, explicit feasibility milestones, and continuation criteria, with recurring submission cycles into the 2027 review cycle.
Application guidance
Use the listings above as a shortlist, then build your application from the official instructions. Save the source page, deadline, eligibility rules, required documents, contact details, and any program-specific scoring criteria. If the deadline is rolling, apply early enough for review queues and budget limits. If the deadline is fixed, work backward from the closing date and leave time for recommendations, institutional approvals, financial documents, and portal errors.
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Federal Grants FAQ
Can individuals get federal grants?
Rarely. Most federal grants go to organizations, governments, universities, and businesses; individuals seeking personal financial help should look at federal benefit programs instead.
What is the difference between a grant and a cooperative agreement?
Both provide federal funding, but a cooperative agreement involves substantial agency involvement in carrying out the work. The notice of funding opportunity states which instrument is used.
Where do federal grant applications actually happen?
Through official government systems such as Grants.gov or agency-specific portals, which also require registrations like SAM.gov that can take weeks. Never pay a third party to "unlock" federal grants.